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BCCNS Manifestations

 

Basal Cell Carcinoma Nevus Syndrome (BCCNS, also identified as nevoid basal cell carcinoma syndrome, Gorlin syndrome, and Gorlin-Goltz syndrome) results from a mutation of the PTCH tumor-suppressing gene, affecting the Hedgehog signaling pathway in the body's cells. It is a dominant genetic disorder, meaning that someone with BCCNS has a 50-percent chance of passing the disorder on to each child.

The criteria for diagnosis and brief definitions are listed here, along with other symptoms associated with BCCNS. Diagnosis requires EITHER two of the major criteria OR one major criterion and two minor criteria. Please be aware that no one will develop every symptom listed here.

Information can also be found on MedlinePlus, a service of the U.S. National Library of Medicine.

 

The information in this web site is for educational purposes only, and is not providing medical or professional advice.
It should not be used for diagnosing or treating a health problem or disease. It is not a substitute for
professional medical care. If you have or suspect you might have any health problems, you should consult a physician.

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